Expression of COX-1, COX-2, iNOS and p38 in Human Brain with Stroke Lesions
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چکیده
منابع مشابه
COX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitors.
Despite the considerable range of newly identified disease modifying approaches to the control of the inflammatory process reported over the past 10–20 years, only a few have yet gained widespread clinical acceptance. In contrast, the very recent advent of the class of anti-inflammatory agents termed COX-2 selective inhibitors is already having a significant impact on current clinical prescribi...
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Ulcerative colitis (UC) is a nonspecific inflammatory disorder characterized by oxidative and nitrosative stress, leucocyte infiltration and up-regulation of pro-inflammatory cytokines. Mitogen-activated protein kinases (MAPKs), such as the p38 and the c-Jun N-terminal kinase (JNK) modulate the transcription of many genes involved in the inflammatory process. Curcumin is a polyphenol derived fr...
متن کاملEvaluation of Expression of EGFR, HER-2 and COX-2 in Colorectal Cancer
Background and objective: EGFR and HER-2 are two members of ERbB/HER family of Type I Transmembrane growth factor receptors. Cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. The aim of this study was to determine the level of expression of EGFR, HER-2 and Cox2 in colorectd cancer. Mater...
متن کاملStreptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium.
Streptococcus pneumoniae is a major cause of community-acquired pneumonia and death from infectious diseases in industrialized countries. Lung airway and alveolar epithelial cells comprise an important barrier against airborne pathogens. Cyclooxygenase (COX)-derived prostaglandins, such as PGE(2), are considered to be important regulators of lung function. Herein, we tested the hypothesis that ...
متن کاملStreptococcus pneumoniae induced p38 MAPK- and NF- B-dependent COX-2 expression in human lung epithelium
Philippe Dje N’Guessan, Stefan Hippenstiel, Mirabelle O. Etouem, Janine Zahlten, Wiebke Beermann, David Lindner, Bastian Opitz, Martin Witzenrath, Simone Rosseau, Norbert Suttorp, and Bernd Schmeck Department of Internal Medicine/Infectious Diseases and Respiratory Medicine, and Institute for Periodontology and Synoptic Dentistry, Charité Centrum 3 for Dental Medicine, Charité-Universitätsmediz...
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ژورنال
عنوان ژورنال: International Journal of Pharmacology
سال: 2008
ISSN: 1811-7775
DOI: 10.3923/ijp.2008.108.113